The pre-eminence of intracellular aluminium associated with non-neuronal cells was a standout observation in autism brain tissue and may offer clues as to both the origin of the brain aluminium as well as a putative role in autism spectrum disorder. While aluminium was imaged associated with neurones it appeared to be present intracellularly in microglia-like cells and other inflammatory non-neuronal cells in the meninges, vasculature, grey and white matter.
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These are some of the highest values for aluminium in human brain tissue yet recorded and one has to question why, for example, the aluminium content of the occipital lobe of a 15 year old boy would be 8.74 (11.59) μg/g dry wt.? Aluminium-selective fluorescence microscopy was used to identify aluminium in brain tissue in 10 donors. Download TheBrain: Dynamic Mind Mapping, Note Taking and Information Management for iOS to described by Wall Street Journal as Software that thinks like you do and MacLife as the most compelling. for the occipital, frontal, temporal and parietal lobes respectively. The aluminium content of brain tissue in autism was consistently high. Much of the tissue injury produced by endotoxin is thought to.
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A 30-day trial version of TheBrain 9 Pro is available for download for Windows and Mac. Perpetual and monthly license arrangements are also available, and are described in detail on TheBrain’s Store web page. We have also used an aluminium-selective fluor to identify aluminium in brain tissue using fluorescence microscopy. The heavy metal lead (Pb) markedly augments the lethality of endotoxin in laboratory animals. If you haven’t previously used TheBrain, a one-time license for version 9 is US219.
Herein we have used transversely heated graphite furnace atomic absorption spectrometry to measure, for the first time, the aluminium content of brain tissue from donors with a diagnosis of autism. Human exposure to the environmental toxin aluminium has been linked, if tentatively, to autism spectrum disorder. It is suggested to involve both genetic susceptibility and environmental factors including in the latter environmental toxins. Autism spectrum disorder is a neurodevelopmental disorder of unknown aetiology.
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